From: Electronic cigarettes: overview of chemical composition and exposure estimation
Agent | Toxicological Endpointa | Value [mg/kg bw/day] | Type of endpointb | Reference |
---|---|---|---|---|
Nicotine | Heart rate acceleration in humans | 0.008 | LOAELc | |
0.0008 | ADI | |||
Glycerol | 2-year study in rats, no effects observed | 10,000 | NOAEL | |
1,2-Propanediol | 2-year studies in rats and dogs, no effects observed in rats, increased erythrocyte destruction in dogs | 2,500 | NOAEL | |
25 | ADI | |||
Ethylene glycol | Developmental toxicity data in mice (total malformations and a skeletal variation) | 76 | BMDL10 | ATSDR [33] based on Neeper-Bradley et al. [46] and Tyl et al. [47] |
0.8 | MRL | |||
1,3-Propanediol | Developmental toxicity study in rats | 1,000 | NOAEL | EFSA Panel on Contaminants in the Food Chain [34] based on unpublished data |
Thujone | Clonic seizures in rats | 11 | BMDL10 | |
0.11 | ADI | |||
Ethyl vanillin | 13-week study in rats, no effects observed | 500 | NOEL | JECFA [35] based on unpublished data |
3 | ADI |